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September 10, 2025CureusOpen Access

Diagnostic Accuracy of 4D CT in Detecting Parathyroid Adenoma Compared With Ultrasound and Sestamibi SPECT/CT in Primary Hyperparathyroidism: A Retrospective Study

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Authors

SGSomdatta GiriKNKrishnan NagarajanBKBalamourougan Krishnaraj

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Overview

Retrospective analysis demonstrates 4D CT's higher sensitivity and localization success in parathyroid adenomas, indicating its potential as a superior imaging modality.

Key Points

  • 4D CT accurately localized parathyroid adenomas in 94.3% of cases, outperforming ultrasound and sestamibi SPECT/CT.
  • With a sensitivity of 88.2%, 4D CT identified significantly more lesions than ultrasound and sestamibi SPECT/CT, particularly in small adenomas.
  • Dynamic enhancement patterns on 4D CT effectively distinguished adenomas from mimics, enhancing diagnostic reliability in primary hyperparathyroidism.
  • The fixed percentage arterial enhancement cutoff showed limitations, highlighting the necessity for individualized diagnostic thresholds.

Cite This Study

Giri et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d6479230bhttps://doi.org/10.7759/cureus.89110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Primary Hyperparathyroidism: 18F-Fluorocholine PET/CT vs. 4D-CT for Parathyroid Identification: Toward a Comprehensive Diagnostic Framework—An Updated Review and Recommendations2025
  2. 2Diagnostic Performance of Imaging Modalities in Persistent or Recurrent Hyperparathyroidism: A Network Meta-Analysis of 18F-Fluorocholine PET/CT, 4D-CT, and Scintigraphy2025
  3. 3Four-dimensional Computed Tomography Imaging in Primary Hyperparathyroidism: Multireader Multicase Study of Both Neuroradiologists and General Radiologists of Imaging Approaches With Less Phases2025
  4. 4Is the 18F-choline PET-CT more cost-effective than standard protocol for locating a parathyroid adenoma?2025
  5. 5Occult Parathyroid Lesions on 99mTc-Sestamibi Scintigraphy: Morphometric, Histopathological and Anatomical Determinants of Detection2026