September 10, 2025Journal of Clinical MedicineOpen Access

Primary Hyperparathyroidism: 18F-Fluorocholine PET/CT vs. 4D-CT for Parathyroid Identification: Toward a Comprehensive Diagnostic Framework—An Updated Review and Recommendations

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Discussion

Updated review finds 18F-fluorocholine PET/CT and 4D-CT enhance parathyroid identification, suggesting a multimodal diagnostic approach.

FCH-PET demonstrates exceptional sensitivity of 94% per patient and 96% per lesion for detecting parathyroid adenomas.
4D-CT provides detailed anatomical imaging, aiding the localization of challenging parathyroid cases, including ectopic glands.
Both imaging techniques show similar diagnostic performance, indicating they could be complementary for preoperative planning.
A multimodal approach is recommended, utilizing initial imaging followed by advanced techniques when uncertainty arises.

Scerrino et al. (2025) studied this question.

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