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September 5, 2025Journal of Computer Assisted TomographyOpen Access

Four-dimensional Computed Tomography Imaging in Primary Hyperparathyroidism: Multireader Multicase Study of Both Neuroradiologists and General Radiologists of Imaging Approaches With Less Phases

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Authors

JKJ KrólRDRobin J.A. DuteweertLDLaura N. Deden

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Overview

Retrospective analysis shows reduced phase protocols maintain diagnostic performance in patients, suggesting improved imaging strategies.

Key Points

  • All evaluated reduced phase protocols were found to be noninferior to the standard four-phase approach.
  • Sensitivity ranged from 0.64 to 0.70, while specificity was higher, between 0.94 and 0.97 for the total group.
  • Neuroradiologists performed well using 1 to 3-phase protocols, but general radiologists required at least 3 phases for optimal results.
  • The enhancement map was helpful as a supplementary tool but did not enhance sensitivity or specificity for adenoma detection.

Cite This Study

Król et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64778eachttps://doi.org/10.1097/rct.0000000000001794
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic Accuracy of 4D CT in Detecting Parathyroid Adenoma Compared With Ultrasound and Sestamibi SPECT/CT in Primary Hyperparathyroidism: A Retrospective Study2025
  2. 2Primary Hyperparathyroidism: 18F-Fluorocholine PET/CT vs. 4D-CT for Parathyroid Identification: Toward a Comprehensive Diagnostic Framework—An Updated Review and Recommendations2025
  3. 3Diagnostic Performance of Imaging Modalities in Persistent or Recurrent Hyperparathyroidism: A Network Meta-Analysis of 18F-Fluorocholine PET/CT, 4D-CT, and Scintigraphy2025
  4. 4Combining 4DCT and [18F]choline PET/CT as first-line imaging in primary hyperparathyroidism patients; a one-stop shop2025
  5. 5The role of radionuclide diagnostics in the algorithm of complex preoperative topical visualization of parathyroid glands in patients with concomitant thyroid diseases2025