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September 10, 2025Bioscientia Medicina Journal of Biomedicine and Translational ResearchOpen Access

Stratifying Neurological Severity in Acute Ischemic Stroke: The Independent and Combined Prognostic Value of Admission D-Dimer and High-Sensitivity C-Reactive Protein

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Authors

SDSyufriyadi DSZLZulfikar LubisCBChairil Amin Batubara

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Overview

Prospective analysis found D-Dimer and hs-CRP predict neurological severity in acute ischemic stroke, suggesting improved risk stratification.

Key Points

  • Admission levels of D-Dimer and hs-CRP independently predict neurological severity in acute ischemic stroke patients.
  • In a cohort of 60 AIS patients, 51.7% were classified with severe stroke based on NIHSS scores.
  • Combining D-Dimer and hs-CRP provided a significant predictability boost with an AUC of 0.92 in ROC analysis.
  • Elevated D-Dimer and hs-CRP were confirmed as independent predictors of severe stroke in multivariate logistic regression.

Cite This Study

DS et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d64790a53https://doi.org/10.37275/bsm.v9i10.1396
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of D-dimer Levels in Acute Ischaemic Stroke Patients at Tertiary Care Centre in Northern India: A Prospective Observational Study2025
  2. 2Admission Uric Acid, Troponin, and C-Reactive Protein Levels and In-Hospital Mortality in Acute Stroke Patients2026
  3. 3Admission D-dimer is associated with subsequent cardiac rupture after acute myocardial infarction: a frequency-matched case-control study2026
  4. 4Inverse Association Between D-Dimer Levels and Glasgow Coma Scale Scores in Hemorrhagic Stroke Patients: A Cross-Sectional Study2025 · 1 citations
  5. 5The relationship between inflammatory markers and the severity and prognosis of neurological dysfunction in stroke patients2026