Randomized trial explores how inflammatory indicators relate to stroke severity and prognosis in patients, suggesting new treatment strategies.
Key Points
This study investigates how inflammatory markers correlate with neurological dysfunction severity and prognosis in acute ischemic stroke patients.
Recruited 225 acute ischemic stroke patients and 46 healthy individuals for clinical and hematological data collection.
Evaluated inflammatory markers and neurological function using NIHSS and mRS scores at multiple time points (admission, discharge, 1 month, 3 months).
Utilized correlation analysis, multivariate logistic regression, ROC curve, and AUC to determine relationships between markers and stroke outcomes.
Higher neutrophil to lymphocyte ratio, systemic immune-inflammation index, systemic inflammatory response index, and pan immune-inflammation value observed in patients at admission (p < 0.05).
Positive correlations between inflammatory markers and neurological severity noted, particularly at admission and discharge.
NLR showed the best prognostic value at admission (AUC = 0.654) and PIV at discharge (AUC = 0.725).