Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Annals of JointOpen Access

Genome-wide association assessment between immune cells and osteoarthritis: a bidirectional Mendelian randomization study

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJ ZhengYSYujun SunWLWenzhou Liu

Discussion

Loading...

Member takes

Overview

Bidirectional Mendelian randomization reveals immune cell traits significantly influence osteoarthritis, suggesting new treatment avenues.

Key Points

  • Thirteen immune cell traits showed significant causal relationships with osteoarthritis.
  • The strongest effects on OA were linked to specific monocyte phenotypes with OR values indicating notable risk levels.
  • Bidirectional Mendelian randomization methodology utilized GWAS data to assert causal connections between immune cells and OA.
  • Findings support the potential for novel immunological treatments targeting immune cell phenotypes in osteoarthritis.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d64790707https://doi.org/10.21037/aoj-24-60
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Complex causal association between immune cells and psoriatic arthritis: A bidirectional Mendelian randomization study2025
  2. 2Genetically predicted immune cells and metabolites mediate the causal relationship between inflammatory factors and rheumatoid arthritis2025
  3. 3Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis2026
  4. 4A Mendelian randomization study of the gut microbiota and risk of knee osteoarthritis and the mediating role of immune cells2025
  5. 5Causal Associations of the Alterations in Peripheral Blood Immune Cell Characteristics on the Incidence of Osteoporosis: A Bidirectional Mendelian Randomization Study2025