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September 10, 2025Scientific ReportsOpen Access

A Mendelian randomization study of the gut microbiota and risk of knee osteoarthritis and the mediating role of immune cells

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Authors

JZJiayu ZhangXQXiuyue Qiu

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Overview

Mendelian randomization reveals the connection between gut microbiota and knee osteoarthritis, suggesting immune cells play a crucial role.

Key Points

  • A causal relationship exists between gut microbiota and knee osteoarthritis, impacting immune cell activity.
  • Mendelian randomization analysis identified 20 gut microbiota linked to an increased risk of knee osteoarthritis.
  • Specific immune cells, including CCR7 on naive CD4+ and activated Tregs, mediate the effects of gut microbiota on knee osteoarthritis.
  • Findings highlight the potential for developing new prevention strategies for knee osteoarthritis based on gut microbiota.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479cf8bhttps://doi.org/10.1038/s41598-025-14007-x
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