Bidirectional Mendelian randomization reveals immune cells and metabolites as mediators in rheumatoid arthritis progression.
Key Points
Elevated levels of the inflammatory factor CD40L receptor positively correlate with increased rheumatoid arthritis risk.
Mediation analysis identifies CD14+CD16- monocytes and X-24757 as significant mediators, with specific odds ratios indicating strong effects.
A bidirectional Mendelian randomization approach utilizes genome-wide association study data for causal assessments of RA and inflammatory factors.
Findings suggest that immune cells and metabolites play crucial roles in the pathogenesis of rheumatoid arthritis, highlighting potential therapeutic targets.