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September 10, 2025Journal of Multidisciplinary HealthcareOpen Access

Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study

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Authors

GDGuangyu DuDXDaikang XuZHZhao Hai

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Overview

Observational analysis finds potential causal associations between metabolites and meningiomas, suggesting new biomarkers.

Key Points

  • Identified 36 metabolites associated with meningiomas, indicating potential new biomarker targets.
  • Utilized Mendelian randomization to analyze 486 plasma and 338 CSF metabolites from 1,835 cases and 377,674 controls.
  • Applied the Inverse Variance Weighted method with FDR correction, enhancing the reliability of findings.
  • Found positive and negative causal relationships, notably between Glycerol 3-phosphate and Valine with meningioma incidence.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6478ff9fhttps://doi.org/10.2147/jmdh.s527449
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Also Consider

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