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October 1, 2025MedicineOpen Access

The role of cerebrospinal fluid metabolites in the pathogenesis of lung adenocarcinoma: An observational study using Mendelian randomization

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Authors

XZXingcheng ZhuYFYuanzhi FuLZLin Zhu

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Overview

Observational analysis reveals how cerebrospinal fluid metabolites may influence lung adenocarcinoma risk, suggesting complex metabolic interactions.

Key Points

  • Forward Mendelian randomization identified 7 cerebrospinal fluid metabolites associated with lung adenocarcinoma risk, highlighting their potential roles.
  • The study involved analyzing data from 11,273 lung cancer patients and 55,483 controls, focusing on genetic variants linked to each metabolite.
  • Two-sample Mendelian randomization was employed alongside sensitivity analyses to assess the robustness of the findings regarding causality.
  • The implications of these findings suggest that cerebrospinal fluid metabolites might significantly contribute to lung adenocarcinoma development.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc4990d8https://doi.org/10.1097/md.0000000000044710
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