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September 10, 2025Cardiovascular DiabetologyOpen Access

Predictive value of the combined triglyceride-glucose and frailty index for cardiovascular disease and stroke in two prospective cohorts

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Authors

YZYi‐Chang ZhaoSWShiqi WuJLJia-Kai Li

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Overview

Research shows higher triglyceride-glucose and frailty index levels increase CVD and stroke risk in aging populations, suggesting a new risk stratification approach.

Key Points

  • Higher levels of the triglyceride-glucose and frailty index combined predict increased risks of cardiovascular disease and stroke in older adults.
  • In CHARLS, the highest quartile of TyGFI was associated with an odds ratio of 15.09 for CVD, indicating a strong predictive value.
  • Multivariable logistic regression analyses were employed across two cohorts, CHARLS and NHANES, to assess risk associations while adjusting for various factors.
  • This research emphasizes the importance of integrating metabolic and functional indicators for enhanced risk assessment in elderly populations.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c23dc5b210217d6478f331https://doi.org/10.1186/s12933-025-02880-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Triglyceride-Glucose-Frailty Index with Cardiovascular Disease and All-Cause Mortality Incidence in Individuals with Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Nationwide Prospective Cohort Study2026 · 1 citations
  2. 2Association of 14 triglyceride-glucose (TyG)-related indices with new-onset cardiovascular disease in middle-aged and older adults: evidence from the CHARLS and ELSA aging cohorts2026 · 1 citations
  3. 3Reassessing of the incremental predictive value of triglyceride-glucose index beyond traditional cardiovascular risk factors: a cohort study based on the China health and nutrition survey and meta-analysis2026
  4. 4Association between the combined cholesterol, high-density lipoprotein, glucose index and frailty index and new-onset cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from CHARLS2026 · 1 citations
  5. 5Evaluating the associations and predictive performance of triglyceride-glucose index and related indicators for chronic diseases in a Chinese cohort2025 · 1 citations