What question did this study set out to answer?

This study aims to evaluate the association between the Triglyceride-Glucose-Frailty Index (TyGFI) and the incidence of cardiovascular disease (CVD) and all-cause mortality in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.

May 30, 2026Journal of Clinical MedicineOpen Access

Association of Triglyceride-Glucose-Frailty Index with Cardiovascular Disease and All-Cause Mortality Incidence in Individuals with Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Nationwide Prospective Cohort Study

View Full Paper

Ask AI

Bookmark

Authors

XYXingsheng Ye YCYuanqi Chen WPWenjie Peng

Discussion

Member takes

Overview

Nationwide prospective cohort study finds TyG-Frailty Index predicts CVD and mortality in those with cardiovascular-kidney-metabolic syndrome stages 0-3, suggesting clinical relevance.

Key Points

This study aims to evaluate the association between the Triglyceride-Glucose-Frailty Index (TyGFI) and the incidence of cardiovascular disease (CVD) and all-cause mortality in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.
Included 6207 individuals for CVD and 6386 for all-cause mortality from the China Health and Retirement Longitudinal Study.
Analyzed data using multivariable Cox proportional hazards models, Kaplan–Meier curves, ROC curves, and mediation analysis.
Conducted subgroup analyses to evaluate differing sociodemographic and clinical characteristics.
TyGFI significantly associated with increased CVD risk (HR = 1.25, 95% CI: 1.18–1.33) and all-cause mortality (HR = 1.39, 95% CI: 1.18–1.63).
Highest TyGFI quartile faced increased CVD risk (HR = 2.02, 95% CI: 1.69–2.42) and mortality (HR = 2.67, 95% CI: 1.33–5.38) compared to the lowest quartile.
Age mediates the effect of TyGFI on CVD (mediation proportion = 9.81%) and mortality (mediation proportion = 32.45%).

Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/6a1a82d50307b785094348f1 https://doi.org/10.3390/jcm15114156

View Full Paper

Ask AI

Bookmark

May 30, 2026Journal of Clinical MedicineOpen Access

Association of Triglyceride-Glucose-Frailty Index with Cardiovascular Disease and All-Cause Mortality Incidence in Individuals with Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Nationwide Prospective Cohort Study

View Full Paper

Ask AI

Bookmark

Authors

XYXingsheng Ye YCYuanqi Chen WPWenjie Peng

Discussion

Member takes

Overview

Nationwide prospective cohort study finds TyG-Frailty Index predicts CVD and mortality in those with cardiovascular-kidney-metabolic syndrome stages 0-3, suggesting clinical relevance.

Key Points

This study aims to evaluate the association between the Triglyceride-Glucose-Frailty Index (TyGFI) and the incidence of cardiovascular disease (CVD) and all-cause mortality in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.
Included 6207 individuals for CVD and 6386 for all-cause mortality from the China Health and Retirement Longitudinal Study.
Analyzed data using multivariable Cox proportional hazards models, Kaplan–Meier curves, ROC curves, and mediation analysis.
Conducted subgroup analyses to evaluate differing sociodemographic and clinical characteristics.
TyGFI significantly associated with increased CVD risk (HR = 1.25, 95% CI: 1.18–1.33) and all-cause mortality (HR = 1.39, 95% CI: 1.18–1.63).
Highest TyGFI quartile faced increased CVD risk (HR = 2.02, 95% CI: 1.69–2.42) and mortality (HR = 2.67, 95% CI: 1.33–5.38) compared to the lowest quartile.
Age mediates the effect of TyGFI on CVD (mediation proportion = 9.81%) and mortality (mediation proportion = 32.45%).

Cite This Study

Ye et al. (2026) studied this question.

synapsesocial.com/papers/6a1a82d50307b785094348f1 https://doi.org/10.3390/jcm15114156

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark