August 21, 2025International Journal of Molecular SciencesOpen Access

Cilastatin Attenuates Acute Kidney Injury and Reduces Mortality in a Rat Model of Sepsis

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Cilastatin treatment improved survival in a rat model of sepsis, reducing mortality by 33%.
Kidney injury was evaluated through multiple biomarkers, including serum creatinine and glomerular filtration rate.
Cecal ligation puncture was performed to induce sepsis in male Sprague-Dawley rats for this evaluation.
Cilastatin may represent a promising therapy for managing inflammation and kidney dysfunction in sepsis.

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Implication

Cilastatin shows promise in preventing acute kidney injury and improving survival rates in sepsis, suggesting a therapeutic role in inflammation management.

Cite This Study

González-Nicolás et al. (2025) studied this question.

synapsesocial.com/papers/68c236dfb210217d64776561 https://doi.org/10.3390/ijms26167927

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Implication

Cilastatin shows promise in preventing acute kidney injury and improving survival rates in sepsis, suggesting a therapeutic role in inflammation management.

Cilastatin Attenuates Acute Kidney Injury and Reduces Mortality in a Rat Model of Sepsis

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Discussion

Implication

Cite This Study

Cilastatin Attenuates Acute Kidney Injury and Reduces Mortality in a Rat Model of Sepsis

Key Points

Discussion

Implication

Cite This Study

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