Enantioselective Synthesis of Spirooxindole Derivatives through Lewis Acid-Catalyzed Michael Addition/Cyclization Cascade

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Asymmetric Michael addition/cyclization creates biologically active spirooxindole derivatives, suggesting potential cancer treatment.

The synthesis achieves excellent yields of spirooxindole derivatives, with yields ranging from 70-99%.
One derivative exhibits significant cytotoxicity against both NCI-H460 human lung cancer and SW-620 human colon cancer cell lines.
The reaction employs Mg(OTf)2 as a Lewis acid to facilitate the Michael addition and cyclization.
This method emphasizes the potential for developing new cancer therapeutics based on unique spirooxindole structures.

Tan et al. (2025) studied this question.

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