September 18, 2025

Asymmetric Organocatalytic Oxidative Michael addition–Electrocyclization Cascade towards the Enantioselective Dihydroisoindole-triones

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Discussion

Observational analysis shows high yields of enantioselective dihydroisoindole synthesis, indicating a novel reaction pathway.

Up to 74% yield and 96% enantioselectivity were achieved in the synthesis of dihydroisoindole-triones.
The method involves an asymmetric organocatalytic cascade facilitated by a camphor sulfonyl-substituted primary amine.
DFT calculations support the proposed reaction mechanism, showing significant exergonicity of key intermediates.
The incorporation of the 1,3-dione moiety allows for further synthetic applications and elaboration.

Gondal et al. (2025) studied this question.

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