August 8, 2025Chinese Journal of Chemistry

Divergent Asymmetric Synthesis of Polycyclic Spiroindolines via Cascade Cycloadditions

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Authors

HZHuan ZhangTianjin University of Technology CMChenchen MaShandong University of Traditional Chinese Medicine FYFuxing YinYantai University

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Implication

This approach demonstrates high yield and precise control of stereochemistry in polycyclic spiroindolines, indicating its potential for diverse applications.

Key Points

Impressive yields up to 81% with excellent stereocontrol in the synthesis of chiral polycyclic spiroindolines.
This method allows the formation of structures with two chiral quaternary stereocenters and one tertiary stereocenter.
Employing an iridium catalyst and Carreira ligand, the approach showcases notable chemoselectivity in cascade cycloadditions.
The process is scalable, suggesting practical applications for the resulting compounds in synthetic chemistry.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af2b56cf1dd9ea359e4174 https://doi.org/10.1002/cjoc.70191

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Implication

This approach demonstrates high yield and precise control of stereochemistry in polycyclic spiroindolines, indicating its potential for diverse applications.

Divergent Asymmetric Synthesis of Polycyclic Spiroindolines via Cascade Cycloadditions

Discussion

Member takes

Implication

Key Points

Cite This Study

Divergent Asymmetric Synthesis of Polycyclic Spiroindolines via Cascade Cycloadditions

Discussion

Member takes

Implication

Key Points

Cite This Study

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