Stereoselective Synthesis of Spirocyclic Indolin-3-ones through a Gold(I)-Catalyzed Cascade Cyclization of Azido-alkynes

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Gold(I)-catalyzed reaction generates spirocyclic indolin-3-ones, showing promising yields and stereoselectivity.

The reaction yields stereoselective spirocyclic indolin-3-ones, which are significant in natural products.
Gold(I)-catalyzed cyclization of azido-alkynes produces an α-imino gold carbene for further reaction.
The methodology allows for a broad substrate scope, resulting in satisfactory yields of diverse indoline-3-ones.
The process showcases the potential of gold(I) catalysts in synthesizing complex molecular motifs efficiently.

Hasegawa et al. (2025) studied this question.

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