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September 10, 2025Translational Cancer ResearchOpen Access

A nine-gene signature with potential targets for predicting the prognosis of patients with esophageal cancer

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Authors

MSMengfei SunYMYandi MaFZFuqiang Zhou

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Overview

Analysis reveals a prognostic risk score model for esophageal squamous cell carcinoma, indicating potential therapeutic targets.

Key Points

  • A nine-gene signature predicts poor prognosis in patients with esophageal cancer, highlighting potential treatment targets.
  • Clinical data showed that high FABP3 expression correlated with shorter overall survival (OS) in patients with esophageal squamous cell carcinoma.
  • RNA sequencing analysis from The Cancer Genome Atlas identified nine prognostic genes, enabling a constructed risk score model.
  • Integration of clinical features with genetic markers in a nomogram allows for improved overall survival predictions in ESCC patients.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64791648https://doi.org/10.21037/tcr-2025-146
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