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December 6, 2025JAC-Antimicrobial ResistanceOpen Access

P28 Assessment of colistin susceptibility in carbapenem-resistant Klebsiella pneumoniae and Escherichia coli : a comparison of diagnostics MIC-COL and VITEK® 2 AST-XN21 with broth microdilution

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FAFatih Mehmet Akıllı

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Overview

This analysis assesses colistin resistance in carbapenem-resistant Enterobacterales, indicating reliable diagnostics may guide therapeutic options.

Key Points

  • Colistin resistance was found in 31.9% of clinical carbapenem-resistant isolates, highlighting a rising concern.
  • Broth microdilution served as the reference standard for assessing colistin susceptibility in this evaluation.
  • Diagnostics MIC-COL showed 100% categorical agreement, outperforming VITEK® 2 AST-XN21 in essential agreement.
  • High prevalence of resistance underscores the urgent need for improved diagnostics and larger multicenter studies.

Cite This Study

Fatih Mehmet Akıllı (2025) studied this question.

synapsesocial.com/papers/69337d09b3f947a0a125ac5chttps://doi.org/10.1093/jacamr/dlaf230.035
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