September 10, 2025Journal of Cell Communication and SignalingOpen Access

Trans‐Coumaryl acetate mediates GRK5/NF‐κB/Nrf2 signaling axis to ameliorate septic acute kidney injury

View Full Paper

Ask AI

Bookmark

T‐CA treatment significantly improved cell viability and reduced inflammation in LPS-treated HK-2 cells.
In septic acute kidney injury mice, T‐CA decreased mitochondrial dysfunction and apoptosis while enhancing antioxidant levels.
The study utilized HK-2 cells and a mouse SAKI model to evaluate T‐CA's protective effects against renal injury.
These findings support T‐CA's potential as a therapeutic agent for septic acute kidney injury through modulation of GRK5/NF‐κB/Nrf2 signaling.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

In vivo and in vitro analysis shows that T‐CA reduces inflammation and oxidative stress in septic acute kidney injury, indicating its therapeutic potential.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a154 https://doi.org/10.1002/ccs3.70044

View Full Paper

Ask AI

Bookmark

Implication

In vivo and in vitro analysis shows that T‐CA reduces inflammation and oxidative stress in septic acute kidney injury, indicating its therapeutic potential.

Trans‐Coumaryl acetate mediates GRK5/NF‐κB/Nrf2 signaling axis to ameliorate septic acute kidney injury

Key Points

Discussion

Implication

Cite This Study

Trans‐Coumaryl acetate mediates GRK5/NF‐κB/Nrf2 signaling axis to ameliorate septic acute kidney injury

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider