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September 5, 2025Food & Function

Cinnamic acid ameliorates diabetic nephropathy in rats via Nrf2 activation and inflammation modulation

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Authors

SASetah Naif AlotaibiGAGhedeir M. AlshammariNANawal A. Albadr

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Overview

Observational analysis reveals reduced renal dysfunction in T2DM rats treated with cinnamic acid, indicating inflammation modulation and Nrf2 pathway involvement.

Key Points

  • Cinnamic acid significantly reduced fasting glucose levels and improved renal function in T2DM rats.
  • Treatment lowered inflammatory marker levels like TNF-α and IL-6, while increasing Nrf2 activation.
  • Cinnamic acid's protective effects were dose-dependent, showing improvements at both 20 mg and 40 mg doses.
  • The addition of brusatol indicated that Nrf2 plays a crucial role in mediating the beneficial effects of cinnamic acid.

Cite This Study

Alotaibi et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d6477885fhttps://doi.org/10.1039/d5fo02465j
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