September 10, 2025Frontiers in PharmacologyOpen Access

Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury

View Full Paper

Ask AI

Bookmark

Chrysophanol protects against sepsis-associated acute kidney injury by modulating macrophage polarization.
The study shows that chrysophanol inhibits inflammatory cytokines TNF-α and IL-6, suggesting a strong anti-inflammatory effect.
In vivo and in vitro results indicate that chrysophanol's protective effects are linked to inhibiting the NF-κB signaling pathway.
Findings highlight chrysophanol as a potential therapeutic agent for SA-AKI, warranting further exploration.

Discussion

No takes yet. Share an insight, caveat, or question.

In vitro and in vivo analysis reveals chrysophanol's role in M2 macrophage polarization, suggesting new SA-AKI treatments.

Gou et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark