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September 10, 2025The FASEB Journal

Targeting Inflammation and Fibrosis in Cardiovascular Disease: Emerging Mechanisms and Therapies

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Authors

HCHéctor A. Cabrera-FuentesGBGuillermo BarretoEPEduardo Pérez‐Campos

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Overview

Review highlights mechanisms of inflammation and fibrosis in cardiovascular disease, suggesting new therapies.

Key Points

  • Emerging therapies may reverse maladaptive remodeling and restore cardiac function.
  • Dysregulated immune responses and ECM remodeling promote myocardial stiffening and adverse cardiac remodeling.
  • Cellular crosstalk among neutrophils, macrophages, and fibroblasts drives pathological fibrosis.
  • Focus on biophysical mechanisms like macrophage polarization and TGF-β signaling enables new therapeutic strategies.

Cite This Study

Cabrera-Fuentes et al. (2025) studied this question.

synapsesocial.com/papers/68d413f8713b0b5dfea61c3chttps://doi.org/10.1096/fj.202500970r
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