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September 10, 2025Endocrine Metabolic & Immune Disorders - Drug Targets

Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing

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Authors

ZLZichao LyuXMXiangyue MengJXJuan Xiao

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Overview

Single-cell RNA sequencing highlights B cell roles in childhood acute lymphoblastic leukemia, suggesting immune interactions are pivotal.

Key Points

  • B cells showed significant enrichment in childhood acute lymphoblastic leukemia samples, indicating their vital role.
  • Four marker genes were identified through RNA sequencing to construct a prognostic model that predicts patient survival.
  • Single-cell RNA sequencing revealed five distinct cell subpopulations, enhancing understanding of immune cell interactions.
  • High-risk childhood acute lymphoblastic leukemia patients had elevated immune infiltration, suggesting potential therapeutic targets.

Cite This Study

Lyu et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789ca2https://doi.org/10.2174/0118715303420113250818064855
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Also Consider

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  1. 1Histone-, Receptor-, and Integrin-Related Gene Products and ADAM28 as Relevant to B-Cell Acute Lymphoblastic Leukemia (B-ALL)2025
  2. 2Data-driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes.2025
  3. 3Transcriptome-based immune subtypes reveal the heterogeneity of tumor microenvironment in pediatric B-cell acute lymphocytic leukemia2025
  4. 4RNA‐seq Molecular Risk Classification Refines Prognostic Stratification in Childhood B‐Cell Acute Lymphoblastic Leukemia Treated With the CCCG‐ALL‐2020 Protocol: A Real‐World Cohort Study2026
  5. 5Application of Targeted RNA‐Sequencing in High‐Risk B‐Cell Acute Lymphoblastic Leukemia (B‐ALL): Identifying Fusions, <i>IKZF1</i> Deletions, and <i>CRLF2</i> Expression in an Indian Cohort2025