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September 5, 2025Current Issues in Molecular BiologyOpen Access

Histone-, Receptor-, and Integrin-Related Gene Products and ADAM28 as Relevant to B-Cell Acute Lymphoblastic Leukemia (B-ALL)

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Authors

MWMarc R. WilkinsBPBrett E Pickett

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Overview

Analysis reveals differentially expressed genes and potential therapeutic targets in B-ALL, suggesting new avenues for treatment.

Key Points

  • Differential gene expression analysis identified upregulation of HIST2H2AA3 and downregulation of IGHA1 in B-ALL.
  • Assessment of RNA-sequencing samples uncovered multiple pathways, including integrins in angiogenesis affected by B-ALL.
  • Pathway enrichment analysis led to the identification of 306 therapeutic targets for B-ALL, three of which are untested in human trials.
  • The study highlights ADAM28 as a potential mechanistic marker for B-ALL, suggesting future research directions.

Cite This Study

Wilkins et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64778f96https://doi.org/10.3390/cimb47090699
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1edgeR : a Bioconductor package for differential expression analysis of digital gene expression data2009 · 45,449 citations