Five distinct immune subtypes of pediatric B-ALL were identified based on immune signatures, indicating significant heterogeneity within the tumor microenvironment.
Cluster 1 showed favorable prognosis with low white blood count, while other clusters demonstrated unfavorable prognostic features and varied immune checkpoints.
Analysis involved two cohorts, with one validating a consensus clustering algorithm focused on immune-related genes impacting prognosis of B-ALL.
Findings support precision therapies tailored to the immune profiles of pediatric B-ALL, reflecting distinct genetic and clinical behaviors.