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September 10, 2025International Journal of Laboratory Hematology

Application of Targeted RNA‐Sequencing in High‐Risk B‐Cell Acute Lymphoblastic Leukemia (B‐ALL): Identifying Fusions, IKZF1 Deletions, and CRLF2 Expression in an Indian Cohort

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Authors

SGSanjeev Kumar GuptaGLGadha K. LeonsPSPreity Sharma

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Overview

Analysis reveals gene fusions and IKZF1 deletions in high-risk B-cell acute lymphoblastic leukemia, suggesting targeted sequencing can enhance diagnosis.

Key Points

  • Targeted RNA sequencing identified gene fusions in 22% of high-risk B-cell acute lymphoblastic leukemia cases, highlighting its utility.
  • IKZF1 deletions were found in 75% of samples positive for gene deletions, indicating a significant occurrence in the cohort.
  • Flow-cytometry confirmed CRLF2 overexpression in 60% of cases, correlating with targeted RNA sequencing findings.
  • This study emphasizes the potential of targeted sequencing for discovering novel genomic alterations in B-ALL.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d6478297bhttps://doi.org/10.1111/ijlh.14551
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNA-sequencing improves risk stratification and guides treatment decision-making in acute lymphoblastic leukemia- a UK single centre experience2025 · 1 citations
  2. 2Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome Sequencing2025
  3. 3Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing2025
  4. 4Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia2025 · 1 citations
  5. 5Clinical value of advanced genomic testing in adult Philadelphia-negative B-ALL: Results from the CZ national leukemia study group (CELL)2025