Comparative effectiveness of antibiotic prophylaxis for preventing serious adverse events after primary total hip arthroplasty: a systematic review and network meta-analysis of randomized trials
Systematic review evaluates antibiotic prophylaxis impact on serious adverse events in total hip arthroplasty, suggesting limited superiority of multi-day regimens.
Key Points
Antibiotic prophylaxis may lower serious adverse events after total hip arthroplasty, showing some benefits across most strategies but no strong evidence for prolonged use.
Lower odds of serious adverse events (OR=0.87) were observed for short-term antibiotic use compared to placebo, though results had very low certainty.
Systematic review and network meta-analysis included 10 randomized trials, assessing multiple strategies of antibiotic duration related to outcomes after surgery.
Findings indicate that while most antibiotic regimens may reduce serious adverse events, evidence supporting extended use is inconclusive and requires cautious interpretation.