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September 10, 2025

Mechanism of piR-hsa-26925 in regulating invasion and metastasis of lung adenocarcinoma via METTL3-mediated m6A methylation modification.

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Authors

YLY Q LuoNWNing WangJLJ P Li

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Overview

Observational study shows piR-hsa-26925 enhances invasion and metastasis in lung adenocarcinoma, implying METTL3 involvement.

Key Points

  • piR-hsa-26925 significantly promotes lung adenocarcinoma migration and invasion.
  • Knockdown of piR-hsa-26925 decreased E-cadherin and increased vimentin, enhancing cell migration.
  • piR-hsa-26925 interacts with METTL3, modulating m6A levels of EPHB2, a key regulator in malignancy.
  • Using METTL3 inhibitors altered cell invasion dynamics, highlighting therapeutic potential.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787ea5https://doi.org/10.3760/cma.j.cn112137-20250121-00176
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells2025 · 1 citations
  2. 2The methyltransferase METTL3 promotes the progression of breast cancer cells via regulating EGF m6A modification2025 · 3 citations
  3. 3The m6A demethylase METTL14 inhibits the development and progression of lung squamous cell carcinoma by upregulating CD19+ IgD− CD38dim2025
  4. 4METTL14/IGF2BP2-mediated m6A modification of PD-L1 promotes proliferation, metastasis, and immune escape in high-grade gliomas2025 · 6 citations
  5. 5METTL3-mediated circ_0003998 serves as oncogene in non-small cell lung cancer through regulating miR-330-5p/CXCL3 axis2025 · 2 citations