Research demonstrates circRNA involvement in non-small cell lung cancer by regulating the miR-330-5p and CXCL3 axis, highlighting a potential new treatment strategy.
Key Points
Circ_0003998 is significantly overexpressed in non-small cell lung cancer tissues and cells.
Suppression of circ_0003998 decreases cell growth, migration, and angiogenesis in non-small cell lung cancer.
Circ_0003998 acts as a sponge for miR-330-5p, affecting the regulation of CXCL3 in cancer cell behaviors.
METTL3 enhances circ_0003998 expression through m6A modification, linking it to tumorigenesis in non-small cell lung cancer.