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October 10, 2025Cell Cycle

The methyltransferase METTL3 promotes the progression of breast cancer cells via regulating EGF m6A modification

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Authors

JLJ.-X. LiuFHFang HanXYXinhao Yang

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Overview

In vitro METTL3 knockdown reduces proliferation and migration in breast cancer cells, suggesting EGF signaling's role.

Key Points

  • METTL3 enhances EGF mRNA stability, promoting breast cancer cell proliferation and migration.
  • In vivo experiments confirmed METTL3's role in tumor formation and negative prognosis in breast cancer.
  • Knockdown of METTL3 led to reduced sensitivity to gefitinib and adriamycin in breast cancer cells.
  • The study identifies METTL3 as a potential target to overcome chemotherapeutic resistance in breast cancer.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68e962596210319498c3007ahttps://doi.org/10.1080/15384101.2025.2570258
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