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August 14, 2025Journal of Neuropathology & Experimental Neurology

METTL14/IGF2BP2-mediated m6A modification of PD-L1 promotes proliferation, metastasis, and immune escape in high-grade gliomas

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Authors

ZZZexiang ZhangXGXiaoyu GuoTQT. F. Qi

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Overview

Experimental analysis shows altered m6A modifications on PD-L1 in glioblastoma, indicating roles in tumor growth and immune evasion.

Key Points

  • M6A modification of PD-L1 enhances glioblastoma proliferation and immune escape, potentially worsening patient outcomes.
  • Mettl14 knockdown reduced tumor growth in xenografts, demonstrating a key role in GBM progression.
  • Observational analysis of tumor samples revealed upregulation of METTL14 and PD-L1 levels in GBM tissues and cells.
  • This research highlights a crucial mechanism linking m6A modification and immune evasion in high-grade gliomas.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771cb8https://doi.org/10.1093/jnen/nlaf090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1METTL14 Enhances Anti-Tumor Immunity through m6A-dependent loss of PD-12025
  2. 2The role of METTL14 in the progression of chronic myeloid leukemia2025 · 4 citations
  3. 3The m6A demethylase METTL14 inhibits the development and progression of lung squamous cell carcinoma by upregulating CD19+ IgD− CD38dim2025
  4. 4M6A RNA METHYLATION AS A THERAPEUTIC TARGET IN HIGH GRADE GLIOMA2025
  5. 5The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy2025