September 10, 2025Journal of Neurochemistry

Juvenile Rats Exposed to Antibiotics Early in Life Display Sexual Dimorphisms on Social Behaviour and Sex Hormone Deconjugating Activity

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Early life exposure to antibiotics reduces social interaction in juvenile rats and alters sex hormone activity.
Behavioural tests indicated a significant decrease in social play and grooming among treated males.
Three-way ANOVA showed early life antibiotic exposure significantly diminished juvenile social behaviours.
Findings highlight how early gut microbe interactions could affect hormonal regulation and behaviour in later life.

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Implication

Observational analysis reveals that early life exposure to antibiotics alters social behaviour and hormone activity in juvenile rats, suggesting a role for gut microbes.

Cite This Study

Kuehnel et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787d87 https://doi.org/10.1111/jnc.70224

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Implication

Observational analysis reveals that early life exposure to antibiotics alters social behaviour and hormone activity in juvenile rats, suggesting a role for gut microbes.

Juvenile Rats Exposed to Antibiotics Early in Life Display Sexual Dimorphisms on Social Behaviour and Sex Hormone Deconjugating Activity

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Implication

Cite This Study

Juvenile Rats Exposed to Antibiotics Early in Life Display Sexual Dimorphisms on Social Behaviour and Sex Hormone Deconjugating Activity

Key Points

Discussion

Implication

Cite This Study

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