September 5, 2025Open Access

Early-life microbiota disruption by antibiotics elicits fitness trade-offs that differ by sex

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Early-life antibiotic exposure alters gut microbiome, leading to increased visceral adiposity in males.
Males showed reduced lean mass and energy expenditure, while females showed no proximate metabolic changes.
High-dose antibiotics constrained growth and energy availability, compromising fitness in adult males.
Developmental responses differ by sex, highlighting long-term health impacts related to nutritional conditions.

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Observational analysis indicates early-life antibiotics alter gut microbiome and fitness in mice, suggesting sex differences in metabolic outcomes.

Schell et al. (2025) studied this question.

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Observational analysis indicates early-life antibiotics alter gut microbiome and fitness in mice, suggesting sex differences in metabolic outcomes.