August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Maternal Immune Activation and Estrogen Receptor Modulation Induce Sex-Specific Dopamine-Related Behavioural and Molecular Alterations in Adult Rat Offspring

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Raloxifene treatment improved dopamine-related behaviours in male MIA offspring, while inducing varying effects in females.
In male MIA offspring, raloxifene reduced amphetamine-induced locomotion, highlighting sex-specific responses.
Chronic treatment involved administering raloxifene to offspring and assessing behaviours along with molecular changes.
Findings suggest maternal immune activation affects dopamine dysregulation, with implications for schizophrenia's treatment.

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Implication

Observational analysis indicates raloxifene alters dopamine-related behaviours in male offspring, suggesting potential therapeutic effects for schizophrenia.

Cite This Study

Debs et al. (2025) studied this question.

synapsesocial.com/papers/68af2ee5cf1dd9ea359e676f https://doi.org/10.1093/ijnp/pyaf052.102

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Implication

Observational analysis indicates raloxifene alters dopamine-related behaviours in male offspring, suggesting potential therapeutic effects for schizophrenia.

Maternal Immune Activation and Estrogen Receptor Modulation Induce Sex-Specific Dopamine-Related Behavioural and Molecular Alterations in Adult Rat Offspring

Key Points

Discussion

Implication

Cite This Study

Maternal Immune Activation and Estrogen Receptor Modulation Induce Sex-Specific Dopamine-Related Behavioural and Molecular Alterations in Adult Rat Offspring

Key Points

Discussion

Implication

Cite This Study

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