September 10, 2025Journal of NeurochemistryOpen Access

Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats

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Early life social isolation impaired social reward processing in male rats, but not in females.
Males exhibited downregulated BDNF signaling, while females showed increased BDNF activity after isolation.
Using a social isolation protocol from postnatal day 14–21, both male and female rats were tested across developmental stages.
These findings underscore the need to consider sex-specific biological responses to early life social stress.

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Implication

This study investigates early life social isolation's impact on social reward processing and BDNF signaling in male and female rats, highlighting sex-dependent mechanisms.

Cite This Study

Trapano et al. (2025) studied this question.

synapsesocial.com/papers/68c241acb210217d6479ff38 https://doi.org/10.1111/jnc.70181

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Implication

This study investigates early life social isolation's impact on social reward processing and BDNF signaling in male and female rats, highlighting sex-dependent mechanisms.

Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats

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Implication

Cite This Study

Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats

Key Points

Discussion

Implication

Cite This Study

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