September 10, 2025Journal of Lipid ResearchOpen Access

Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue

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Discussion

Knockout of endothelial SR-B1 shows no effect on thermogenesis, suggesting its role in cholesterol regulation in brown adipose tissue.

Endothelial SR-B1 knockout does not affect thermogenesis in brown adipose tissue, showing no change in energy expenditure.
Mice lacking SR-B1 had lower cholesterol uptake in heart and brown adipose tissue compared to controls, emphasizing its selective regulatory role.
Indirect calorimetry and metabolic turnover studies reveal no significant difference in lipid handling genes between knockout and control mice.
The study indicates that while SR-B1 is not essential for thermogenesis, it plays a key role in cholesterol metabolism in specific organs.

Hurkmans et al. (2025) studied this question.

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