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April 15, 2026EMBO Molecular MedicineOpen Access

Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism

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Authors

YWYufei WuXYXiaomei YangYBYu Bai

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Overview

Investigations reveal that scavenger receptor class B type I mitigates diastolic dysfunction in heart failure with preserved ejection fraction, suggesting a protective role.

Key Points

  • This research investigates the role of scavenger receptor class B type I in cardiac microvascular endothelial dysfunction related to heart failure with preserved ejection fraction.
  • Examined the expression of scavenger receptor class B type I in cardiac microvascular endothelial cells.
  • Utilized adeno-associated virus-mediated delivery for reconstituting SR-B1 in mice
  • Conducted transcriptomics and lineage tracing on cardiac endothelial cells to analyze inflammatory responses.
  • SR-B1 deficiency leads to worsened cardiac remodeling and diastolic dysfunction in HFpEF.
  • Increased CXCL10 secretion caused by SR-B1 loss activates T-cells, worsening diastolic dysfunction.
  • CXCL10 levels are elevated in human HFpEF tissue and correlate with higher prevalence of the condition.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0d0fhttps://doi.org/10.1038/s44321-026-00405-9
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Also Consider

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  4. 4Inhibition of Scarb1 on Endothelial Cells Attenuates Pressure Overload-induced Heart Failure Progression2025 · 4 citations
  5. 5Abstract Wed099: Endothelial KLF4 regulates heart failure with preserved ejection fraction2025