Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions
Observational analysis reveals SIRT1 preserves insulin sensitivity and thermogenic responses in white adipose tissue, highlighting its role in combating inflammation.
Key Points
SIRT1 overexpression protects against reduced insulin signaling and thermogenesis in white adipose tissue under inflammatory stress.
Increased UCP-1 levels were noted in white adipose tissue of SIRT1 overexpressing mice compared to wild type.
The study employed in vivo and in vitro approaches to measure insulin and norepinephrine responses in adipocytes.