August 12, 2025

The TBLR1/TBL1 Co-Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure.

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Discussion

Analysis demonstrates reduced energy expenditure in transgenic mice lacking TBL1 and TBLR1, indicating corepressor roles in BAT thermogenesis.

Deletion of TBL1 and TBLR1 impairs β-adrenergic-induced lipolysis and mitochondrial respiration.
Transgenic mice showed decreased energy expenditure and lower core body temperature during prolonged cold.
The study utilizes transgenic mouse models to explore the role of TBLR1 and TBL1 in thermogenesis.
Identifying TBLR1/TBL1 complex roles highlights potential therapeutic targets for energy homeostasis issues.

Köker et al. (2025) studied this question.

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Analysis demonstrates reduced energy expenditure in transgenic mice lacking TBL1 and TBLR1, indicating corepressor roles in BAT thermogenesis.