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September 10, 2025

Effects of Nrf-2/HO-1, NF-κB/Cox-2/TLR-4, and Bax/Bcl-2/caspase-3 pathways in alleviating azithromycin-induced cardiotoxicity in rats: Potential cardioprotective role of crocin.

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Authors

TDTuba DoğanBYBetül Apaydın YıldırımKKKübra Asena Terim Kapakin

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Overview

Experimental design demonstrated crocin's role in reducing oxidative stress and apoptosis in cardiac tissue, suggesting its cardioprotective effects.

Key Points

  • Crocin treatment effectively reduced azithromycin-induced oxidative stress and apoptosis in cardiac tissue.
  • Key biomarkers like nrf-2 and ho-1 showed enhanced antioxidant status, while inflammatory markers nf-κb and TLR-4 were down-regulated.
  • Histological analysis revealed that crocin alleviated degenerative changes in heart tissue caused by azithromycin exposure.
  • Overall, crocin exhibited significant cardioprotective effects by modulating oxidative stress and inflammation.

Cite This Study

Doğan et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d647852bchttps://doi.org/10.22038/ijbms.2025.83518.18069
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigation of the Effects of Chrysin Against Azithromycin-Induced Heart Damage in Rats2025
  2. 2Targeting Keap1/Nrf2/Ho-1 Pathway May Explain the Ameliorative Effect of Carnosic Acid against Cyclophosphamide-Induced Cardiotoxicity2026
  3. 3BS29 Ambroxol attenuates cyclophosphamide cardiotoxicity by suppressing NF-κB/NLRP3 inflammasome axis and oxidative stress, and upregulating NRF2/HO-1 signalling2025
  4. 4L-Carnitine Attenuates Azithromycin-Induced Cardiotoxicity: Electrophysiological and Biochemical Evidence in a Rat Model2026
  5. 5In-silico and In-vivo Investigations Reveal Ameliorative Potential of Myricetin Against Doxorubicin-induced Myocardial Damage via Modulation of NF-κB Signaling Pathway2025