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October 7, 2025Current Protein and Peptide Science

In-silico and In-vivo Investigations Reveal Ameliorative Potential of Myricetin Against Doxorubicin-induced Myocardial Damage via Modulation of NF-κB Signaling Pathway

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Authors

PBPurvaj G. BaroteHPHarshal D. PawarMSM.I. Sayyed

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Overview

In-vivo analysis shows myricetin improves myocardial health in doxorubicin-treated rats, suggesting its protective role against cardiotoxicity.

Key Points

  • Myricetin significantly reduced doxorubicin-induced myocardial injury in rats, highlighting its protective role.
  • Treatment with myricetin decreased levels of cardiac injury markers SGPT, SGOT, CK-MB, and LDH after doxorubicin exposure.
  • Molecular docking confirmed strong binding of myricetin to nf-kb, implicating its role in inflammatory modulation.
  • Myricetin improved cardiac oxidative stress markers and reduced inflammatory cytokines, indicating comprehensive cardioprotection.

Cite This Study

Barote et al. (2025) studied this question.

synapsesocial.com/papers/68e585d0b1e78cc4e5f464dehttps://doi.org/10.2174/0113892037383576250909075917
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myricetin Prevents Doxorubicin-Induced Oxidative Stress and Mitochondrial Apoptotic Pathway in H9C2 Cardiac Cells2025
  2. 2Protective Role of Menthol Against Doxorubicin-Induced Cardiac Injury Through Suppression of TLR4/MAPK/NF-κB Signaling and Oxidative Stress2025
  3. 3Abstract Fri069: The RXFP1 Agonist ML290 Protects Against Doxorubicin-induced Cardiomyocyte Injury <i>in vitro</i>2025
  4. 4Adipose-derived mesenchymal stem cells attenuate doxorubicin-induced cardiomyopathy in rats: association with miR-146a/NF-κB/TLR-4 transcriptional modulation2026
  5. 5Methylene Blue Mitigates Doxorubicin-Induced Cardiotoxicity via KEAP1/NRF2/GPX-4/Caspase3 Modulation2025