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August 21, 2025Frontiers in PharmacologyOpen Access

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

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Authors

YMYeasmin Akter MunniKTKhoa Nguyen TranSJSeon-min Jeon

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Overview

Observational analysis showed 2'-fucosyllactose reduced amyloid-beta and improved cognitive function in AD mice, suggesting therapeutic potential.

Key Points

  • 2'-fucosyllactose improved cognitive function in 5xFAD mice, indicating its potential therapeutic role in Alzheimer's disease.
  • Cognitive performance increased notably in maze tests, with a significant reduction of amyloid-beta plaques observed in treated groups.
  • Assessment using immunohistochemical staining revealed lowered pro-inflammatory cytokine levels following treatment with 2'-fucosyllactose.
  • These findings imply multiple mechanisms of action may be at play for 2'-fucosyllactose, warranting further investigation in human studies.

Cite This Study

Munni et al. (2025) studied this question.

synapsesocial.com/papers/68af409acf1dd9ea359eca8fhttps://doi.org/10.3389/fphar.2025.1598030
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Also Consider

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