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September 10, 2025The Journal of Immunology

CD55hi MAIT cells with elevated cytokine secretion and activation markers serve as potential diagnostic indicators in Sjögren’s disease

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Authors

YGYiming GaoHLHanxi LuoBYBohao Yang

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Overview

Assessment of CD55 expression and cytokine profiles in MAIT cells from Sjögren’s disease patients, suggesting diagnostic potential.

Key Points

  • CD55hi MAIT cells showed significantly higher levels of pro-inflammatory cytokines, supporting their role in Sjögren’s disease.
  • Patients with Sjögren’s disease exhibited upregulated CD55 expression on MAIT cells, indicating a potential diagnostic value.
  • Flow cytometry revealed distinct CD55 expression patterns across different MAIT cell subsets in Sjögren’s disease patients.
  • ROC analysis confirmed the diagnostic capability of CD55hi MAIT cells, paving the way for improved autoimmune disease management.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784bbehttps://doi.org/10.1093/jimmun/vkaf226
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Also Consider

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  5. 5Two sides of the same coin: intrinsic IL-27 signaling drives both TFH cells and exhausted CD4 T cells in a mouse model of Sjögren’s disease 43142025