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October 1, 2025The Journal of Experimental MedicineOpen Access

CD2 and its ligands are involved in development and activation of MAIT cells

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Authors

KZKaiwen ZhuJDJianmin DouBLBin Li

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Overview

This study reveals that CD2 and its ligands are crucial for mait cell activation, suggesting new avenues for treatment.

Key Points

  • CD2 interactions with its ligands are essential for the maturation and activation of mait cells.
  • In humans, mait cells lacking CD2 showed significantly reduced activation in response to antigens.
  • The study utilizes mouse and human models to establish the importance of cd2 and its ligands in mait cell biology.
  • These findings may indicate new therapeutic strategies for diseases associated with mait cells.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499732https://doi.org/10.1084/jem.20250431
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