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December 4, 2025Immunology

GPR56 Outperforms CD319 as a Discriminative Marker for CD4 + Cytotoxic T Lymphocytes and Is Elevated in Primary Sjögren's Syndrome

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Authors

ABAyibaota BahabayiXZXingyue ZengZZZhonghui Zhang

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Overview

Cytotoxicity analysis reveals GPR56's significance in CD4+ T cells of pSS patients, suggesting its role in disease severity.

Key Points

  • Elevated CD4+ GPR56+ T cells correlated with disease severity in primary Sjögren's syndrome, indicating their role in immune responses.
  • Cytotoxic functions of CD4+ CTLs were highlighted, with granzyme B showing co-expression with GPR56 in single-cell RNA sequencing.
  • Transcriptomic analysis demonstrated distinct gene expression profiles between GPR56+ and GPR56− CD4+ T cells, suggesting immune activation pathways.
  • These findings emphasize GPR56's potential as a therapeutic target in autoimmune disorders, particularly in Sjögren's syndrome.

Cite This Study

Bahabayi et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2a9ehttps://doi.org/10.1111/imm.70073
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Also Consider

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  1. 1Heterogeneity of circulating CD57+ cytotoxic cell subsets across disease stage and aggressiveness in cutaneous T cell lymphoma2025
  2. 2CD55hi MAIT cells with elevated cytokine secretion and activation markers serve as potential diagnostic indicators in Sjögren’s disease2025
  3. 3CD226+ B cells in primary Sjögren’s syndrome: a key player in clinical manifestations and disease pathogenesis2025
  4. 4Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival2025
  5. 5Activation of TLR4 pathways is involved in the elevated expression of BAFF receptor, BR3, in peripheral monocytes of patients with Sjögren’s syndrome 23992025