September 10, 2025Aging and DiseaseOpen Access

TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies

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Discussion

Review explores TGF-β's role in atrial fibrosis and its potential for therapeutic intervention.

TGF-β signaling mediates atrial fibrosis, contributing to the development of atrial fibrillation.
Elevated TGF-β is linked to increased collagen production and myofibroblast activation in myocardial diseases.
Exploring targeted therapies against TGF-β offers potential improvements in treating atrial fibrillation.
Modulating TGF-β pathways may enhance the efficacy of antiarrhythmic treatments for patients.

Chen et al. (2025) studied this question.

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