September 10, 2025Frontiers in PhysiologyOpen Access

Role of vascular endothelial dysfunction and metabolic eprogramming of immune cells in the development and ogression of atherosclerosis

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Discussion

Analysis reveals immune cell metabolic reprogramming's role in atherosclerosis, suggesting vascular dysfunction may be a key target.

Atherogenesis involves a complex interplay of vascular endothelial dysfunction and immune cell metabolic changes, exacerbating disease progression.
Endothelial dysfunction leads to changes in energy metabolism, particularly aerobic glycolysis, and altered immune cell function during atherosclerosis.
Both vascular endothelial cells and immune cells adapt metabolically to maintain activation and inflammatory responses in the atherosclerotic microenvironment.
Finding effective therapeutic targets remains controversial, focusing on either correcting endothelial dysfunction or modulating immune cell metabolism.

Guo et al. (2025) studied this question.

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