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September 5, 2025Journal of Biomedical ScienceOpen Access

Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

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Authors

WWWei-Li WangYSYu-Tsung ShihSWShuyi Wei

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Overview

Review reveals how shear stress influences endothelial metabolism in aging, suggesting pathways for atherosclerosis prevention.

Key Points

  • Aging contributes to endothelial cell dysfunction, and this process is linked to atherosclerosis development.
  • Elevated shear stress from laminar flow benefits endothelial cells, while disturbed low shear stress promotes inflammatory responses.
  • Metabolic reprogramming occurs in endothelial cells with aging, particularly affecting glycolysis and mitochondrial function.
  • Targeting endothelial metabolism may offer therapeutic strategies to mitigate atherosclerosis due to aging and fluid shear stress.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477d919https://doi.org/10.1186/s12929-025-01177-z
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  5. 5Aging in the vascular system: lessons from mechanobiology, computational approaches and oxidative stress.2025 · 11 citations