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October 1, 2025Deleted JournalOpen Access

Dysregulated Lipid Metabolism as a Central Driver of Atherosclerotic Plaque Pathology

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Authors

JSJ. SteinbeckAugusta University RIRachel Anne IannottiAugusta University ARAdil RasheedAugusta University

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Implication

Review highlights how elevated lipid levels contribute to atherosclerotic plaque progression and inflammation.

Key Points

Dysregulated lipid metabolism significantly contributes to the development and progression of atherosclerotic plaques.
Elevated low-density lipoprotein levels initiate vascular and immune dysfunction, fueling plaque advancement.
Cellular and molecular mechanisms of lipid species support the development of macrophage foam cells within plaques.
Emerging therapeutic strategies aim to address hyperlipidemia and mitigate its role in cardiovascular disease.

Cite This Study

Steinbeck et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc4993fc https://doi.org/10.3390/lipidology2040017

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